We are seeking a pharmacological postdoctoral fellow to work in Dr. Krebs' lab, in the Department of Nuclear Medicine at MD Anderson Cancer Center. This position will conduct research to ultimately improve the practice of nuclear medicine.

The project(s) involve generating engineered tumor-targeted T cells, to learn isolation of PBMC, cell transduction, flow cytometry to assess transduction and/or subtyping, functionality assays such as cytokine release assays using ELISA, cellular cytotoxicity assays and in vivo studies using mouse models. Vector design. Molecular biology, such as Western blot, qPCR. Learn in vitro evaluation in cell culture studies, such as to assess ligand uptake, binding specificity, and survival assays. In vivo studies include molecular imaging studies with PET and SPECT including pharmacokinetic analyses, and ex vivo biodistribution analyses, autoradiography, and immunohistochemistry. Assessment of treatment efficacy and toxicity, e.g. using caliper measurements, bioluminescence imaging, and blood draws. Learn experimental design, data collection, and analysis. Literature review. Write scientific articles. Develop presentation skills in lab meetings and conferences. Supervising, teaching, and mentoring of students/lab personnel. Build a scientific network through interdisciplinary collaborations and attending and presenting at conferences. Develop grant writing skills and leadership skills. Develop independent research project.

LEARNING OBJECTIVES

1. Learn generating engineered tumor-targeted T cells, evaluate their in vitro functionality and in vivo functionality in tumor-bearing mouse models. Learn techniques used in molecular biology.

2. Learn in vitro and in vivo evaluation of radioactively labeled ligands. Learn analysis of molecular imaging studies and assessment of treatment efficacy and toxicity.

3. Learn experimental design, data analysis and scientific writing. Participate and present in lab meetings and well-known conferences, develop grant writing and leadership skills.

ELIGIBILITY REQUIREMENTS

The ideal candidate will have recently (within three years) been awarded a Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field (e.g., Pharmacology, Imaging Sciences).

Expertise or skills in the following areas are highly desirable: PK/PD modeling, biomathematics, analytical chemistry, radiolabeling, animal experiments, cell culture, flow cytometry.

POSITION INFORMATION

MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000 (https://trainees.mdanderson.org/apply/mdaPostdoctoralFellowStipendFY24.pdf) . depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits (https://www.utsystem.edu/offices/employee-benefits/insurance-0/eligibility) , including medical, dental, paid time off (https://www.mdanderson.org/about-md-anderson/employee-resources/leave.html) , retirement (https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs) , tuition benefits, educational opportunities, and individual and team recognition01/31/2025