This opportunity to join the Department of Pediatrics at the Vagelos College of Physicians and Surgeons at the rank of Associate Research Scientist under the Eosinophilic Gastrointestinal Diseases Program. Columbia University Irving Medical Center is one of the nation's foremost academic health science centers. The Department of Pediatrics at Columbia University Irving Medical Center is the top in comparison with other pediatrics department in the NY region in NIH research funding.

Key Responsibilities

The Eosinophilic Gastrointestinal Diseases Program (PI: Dr. Bailey) seeks an eligible Associate Research Scientist to work on a full-time basis. Our laboratory uses advanced techniques in mouse genetics, 3D organoid culture systems generated from human samples and mouse tissue as well as human pluripotent stem cells to investigate molecular mechanisms of reactive epithelial changes in pediatric eosinophilic esophagitis (EoE) and associated diseases.

The Associate Research Scientist will have responsibilities:

• to acquire the experiences they need to advance their careers.
• to contribute to the program through research accomplishments, personal growth and interaction with others.
• The ideal candidate is a published expert in stem cell and epithelial cell biology, human development and disease, and has considerable experience in designing and conducting research experiments/projects.

Key responsibilities include:

• Within the predetermined research scope and methodology, conducts research in understanding the pathophysiology of pediatric eosinophilic esophagitis (EoE) and discovering novel biomarkers and drug targets for EoE and associated diseases.
• Formulates research hypotheses, designs and conducts experiments, implements statistical analyses for the successful completion of related research projects.
• Participates in weekly work meetings and works in a collegial and cooperative manner with the PI and other co-workers.
• Understands current scientific literature and acts as a scientific resource to the group.
• Assists PI in providing supervision and guidance to students and trainees in the group on their academic activities.
• Writes peer-review articles, presents at scientific meetings, and assists PI with grant applications and progress reports.
• Plays an active role in seeking career and research advice, both from the PI and from other faculty members as appropriate.
• Maintains a positive relationship with the research team, clinical staff, and acts as a wet lab research resource.
• Provides support to wet lab staff to ensure research is successfully implemented, including maintaining an on-site presence, answering questions, and reporting successes and roadblocks to the research team.
• Help facilitate multidisciplinary and multi-site research as needed.
• Performs related duties & responsibilities as assigned/requested.

• Must have a doctorate degree (M.D. or Ph.D.)
• 2-3 years of postdoctoral training required (applicable only for rank of Associate Research Scientist).
• Published expertise in stem cell biology, human development and disease, epithelial cell biology and/or immunology;
• Skills in molecular-cell biology, mouse genetics, culture of primary cells and organoids, immunofluorescence/confocal microscopy, RNA sequencing and single cell analysis approaches. Candidates with experience in informatics and flow cytometry are strongly encouraged to apply, although these are not requirements.
• Consistently strong interpersonal skills and the ability to build and sustain effective working relationships with professionals in other disciplines.
• The ability to create a high-energy results-oriented work environment that encourages colleagues and staff to value each other's contributions.
• The ability to share and celebrate success with colleagues and staff.