Job Description

Are you passionate about unraveling the mysteries of proteins and their role in diseases such as Alzheimer's and cancer? The Wang Laboratory at the Icahn School of Mount Sinai is seeking a motivated researcher to dive into groundbreaking structural biology research. The Associate Researcher will gain hands on experience with cutting edge techniques such as cryo-EM and X-ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their skills and contribute to higher impact projects.

The Associate Researcher will work closely with a multidisciplinary team to express, purify, and analyze proteins of interest, contributing to structural studies that aim to understand the molecular mechanisms underlying disease. The role will involve conducting molecular biology and biochemistry experiments, supporting protein structure determination, and assisting in the preparation of experimental results for publication and presentation.

Qualifications

• Bachelors or Masters degree in science in biochemistry, molecular biology, biophysics or a related field

• 1 - 2 years of research/laboratory experience

• Experience in molecular biology techniques such as PCR, cloning, and protein expression

• Familiarity with cell culture, baculovirus systems or tissue culture work

• Experience with protein purification techniques (e.g. affinity chromatography, gel filtration)

• Strong organizational skills and attention to detail

• Good communications skills and ability to work as part of a team

• Willingness to learn new techniques and solve complex problems

Responsibilities

• Conduct protein expressions in bacterial, insect and mammalian systems

• Purify proteins using techniques such as affinity chromatography, size exclusion chromatography, and other biochemical methods

• Assist in preparing samples for structural studies using cryo-electron microscopy (cryo-EM) and X-Ray crystallography

• Perform routine molecular biology tasks, including cloning, PCR and mutagenesis

• Assist with structural and functional assays, including bio-physical characterization (e.g. fluorescence based assays, electrophoresis)

• Contribute to laboratory maintenance, inventory and organization of reagents and samples

• Participate in weekly laboratory meetings and contribute to research discussions

• Collaborate with lab members on data analysis, and documentation of experimental protocols

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58661 - $74610.87 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.